API key management refers to the secure handling, storage, and usage of API keys to access third-party tools and services. Effective management of API keys is crucial for robust security and seamless system performance, as a compromised key can lead to unauthorized access, data breaches, or service interruptions. The article focuses on best practices, common challenges, and leading devtools for API key management, including secure storage, access control, usage monitoring, rotation, and renewal. Properly handling these keys safeguards against vulnerabilities, ensuring secure and uninterrupted access to essential third-party services, while also maintaining compliance with service agreements and preventing costly penalties or service denials. The article highlights the importance of encryption, access control, auditing and monitoring, routine rotation, and using tools like Infisical to aid in API key management, as part of a broader secrets management strategy.