Synthetic monitoring, as discussed by Yashvardhan Kukreja at GrafanaCONline 2021, is a method to simulate user behavior for testing application performance from a user's perspective, offering valuable insights into large-scale applications. Grafana Cloud's synthetic monitoring plugin is highlighted for its ease of setup and cost-effectiveness, as it requires no coding and allows users to pay only for stored metrics. This approach facilitates the monitoring of End-to-End availability, service-level availability, geographical bottlenecks, and infrastructure-level performance, making it particularly crucial for applications operating across multiple regions. The Grafana Cloud solution provides an automatic dashboard for visualizing synthetic monitoring checks, enhancing the ability to define service-level indicators and agreements around availability and performance. Kukreja emphasizes the plugin's simplicity and efficiency, demonstrated through a live demo, and the session recordings are available on-demand for further learning.