Synthetic Monitoring in Grafana Cloud is a tool designed to simulate user experiences and provide a global perspective on application performance, utilizing probes located in 22 global sites to monitor services. The platform offers the ability to visualize and alert on data, similar to other Prometheus metrics, and includes predefined alerts to simplify the alerting process. Best practices for creating effective Synthetic Monitoring alerts include using recording rules to manage multiple alerts on a single metric, adjusting alert expression ranges to prevent false alerts, and avoiding probe-level alerting due to potential network issues. Users are encouraged to test alert expressions using Grafana Explore to identify potential problems before they occur. Additional resources and support are available for those interested in optimizing their use of Synthetic Monitoring and alerting within Grafana Cloud.