The blog post by Jeffrey White explores the feasibility of running CockroachDB in unconventional environments, specifically on IBM S/390 and ARM64 CPU architectures. The author details the process of setting up a 12-node CockroachDB cluster across three different regions, each using a distinct CPU architecture, cloud provider, and Linux operating system. The goal is to test the interoperability of CockroachDB in these diverse settings rather than optimizing for performance. The setup involves compiling CockroachDB from source to obtain the necessary binaries and using a virtual software-defined network for connectivity. Benchmark tests are conducted to ensure the system functions adequately, demonstrating that despite the heterogeneity, the CockroachDB cluster can operate as a single database. The blog highlights the adaptability of CockroachDB in different environments, suggesting its potential for simplifying deployments.