The best eCommerce website builders for small and medium businesses are Shopify, Square, Ecwid by Lightspeed, BigCommerce, WooCommerce (for adding a shopping cart to an existing WordPress site), and Wix. When choosing an eCommerce platform, consider budget, features, familiarity with website builders, support, analytics, and pricing. Each platform has its strengths and weaknesses, and some may be more suitable for small businesses than others. For example, Shopify is ideal for getting up and running quickly, while Square excels at selling in-person and online. Ecwid by Lightspeed offers a solid free plan, while BigCommerce is geared towards large-volume sellers. WooCommerce is great for adding a shopping cart to an existing WordPress site, and Wix provides a top-tier site builder with solid eCommerce integration. Additionally, there are options for makers and creators who want to sell through marketplaces or build their own stores using smaller platforms like Gumroad or E-junkie. Enterprise eCommerce websites require more upfront investment but offer enterprise-grade tools and service contracts.