This blog post explores the setup of a multi-region YugabyteDB deployment on Kubernetes with Istio for service discovery and security. The authors demonstrate how to set up a synchronously replicated multi-region YugabyteDB cluster on three different Kubernetes clusters in different regions, using Istio's multicluster mesh feature. They also configure global data distribution across these regions, run a sample application against the YugabyteDB cluster, and explore fault tolerance features. Additionally, they install Kiali for observability and provide guidance on next steps for further exploration of multi-region deployment configurations and other features of YugabyteDB.