To integrate Ebean ORM with YugabyteDB, you need to start a YugabyteDB cluster on your local engine and create a new Java-based Play Framework application. You can then create a simple REST API using Ebean ORM on YugabyteDB by defining an Employee model and an EmployeeController that stores and retrieves employee information in the database. The process involves installing YugabyteDB, creating a new Play Framework project, configuring Ebean and YugabyteDB, and compiling and running the server to test the API endpoints. Additionally, you can explore more use cases and testing support for Ebean ORM with YugabyteDB by checking out the Github issue and orm-examples repository.