A growing number of global enterprises are adopting a multi-cloud strategy to support their data infrastructure, driven by the need for reduced operating costs, improved application resilience, enhanced customer experience, and compliance with data regulations. Companies without a multi-cloud strategy risk falling behind competitively, while CTOs face challenges such as optimizing cloud spend, enforcing security across different providers, and migrating workloads between clouds. To design multi-cloud solutions that outweigh the costs, enterprises should choose the right deployment option, select a cross-region data distribution strategy, redefine their disaster recovery (DR) strategy to cater to cloud outages, prioritize security and compliance policies, make full use of cloud elasticity, enable cloud migration and data portability, centralize database tooling and governance, and invest in DevOps and CI/CD tooling. A cloud-native database solution like YugabyteDB can help organizations overcome these challenges and achieve a successful multi-cloud data infrastructure strategy.