This tutorial sets up an ASP.NET project to connect to The Vonage Voice API, allowing users to add phone call abilities to their application. To complete this setup, developers need a Vonage API account and create a virtual phone number. They also need to set up a Vonage application with security and configuration information, generating private keys and creating JSON Web Tokens (JWT) for authentication. The tutorial covers both ASP.NET Web and Core project setups, installing the Vonage .Net SDK and adding configuration files to the project. With this setup, developers can now dive into code and learn how to make a Text-to-Speech phone call in their ASP.NET project with the Voice API.