In order to set up 2FA (two-factor authentication) on a WordPress website, you'll need to create a custom plugin and use the Nexmo Verify API. This setup requires a Vonage API account and involves several steps, including integrating the Nexmo PHP Library into your plugin, setting up user profiles with custom fields for the mobile number and 2FA status, sending verification codes via SMS or call, and validating the code entered by the user. The process also involves hooking into WordPress actions and filters to intercept the login action and validate the code before allowing the user to log in. With this setup, you'll have a secure way to protect your website and its users from unauthorized access.