Working with JSON in Python, developers often need to deal with data in various formats, and JSON is a popular format used in web development. The native Python standard library provides an easy-to-use way to encode and decode JSON, but other libraries like simplejson, ujson, and requests offer additional features or speed benefits. For example, the requests library has a built-in json() method on the response object that can be used to parse JSON data returned from HTTP requests to third-party REST APIs. Additionally, Flask, a lightweight web framework for Python, provides a built-in jsonify function to handle serializing data for responses. The choice of which library to use depends on personal needs and the specific use case.