CakePHP is an open-source web application development framework written in PHP that follows the Model-View-Controller (MVC) architectural pattern and provides a structured and rapid development environment for building web applications. It offers robust and user-friendly features for handling file uploads, including conventions over configuration, database access through Object-Relational Mapping (ORM), form handling and validation, built-in CRUD operations, and more. To create a CakePHP application, one needs to have basic knowledge of PHP and web development concepts, as well as PHP 8.2 installed, along with a MySQL server and Composer. The application can be configured by setting up the database, creating a new table for handling file uploads, and connecting to the database before starting the development server. Once set up, one can create models, controllers, templates, and handle file uploads using CakePHP's built-in features.