You can create a serverless SMS responder using Python and Google Cloud Functions. To do this, you'll need a Twilio account, a Google Cloud account, Python 3.9+, the Google Cloud CLI, and a code editor. You'll use Twilio's Webhook system to receive incoming messages and respond with a random programming joke using Python and the twiML (Twilio Markup Language) format. You can deploy your function to Google Cloud using the gcloud CLI or the Google Cloud Console. Once deployed, you can configure Twilio to send a message to your number and test it by sending a text message back to yourself. The serverless SMS responder is a powerful tool for building scalable communication solutions and can be used as a starting point for more complex messaging applications.