A GraphQL API in Django can be built using the Graphene-Django package. The project starts by setting up a virtual environment, installing necessary packages, and creating a new Django project with an `api` app. The `INSTALLED_APPS` list is updated to include the `graphene-django` package, and the `GRAPHENE` dictionary is added to configure the GraphQL schema. A database model is created using Django's ORM, and data is populated into the database. The GraphQL schema is then implemented using Graphene's classes, including query resolvers that map to the database model. Mutations are also defined for creating, updating, and deleting data. The API is tested using the GraphIQL interface provided by Graphene-Django, and queries can be sent to retrieve data from the server. Postman can be used to send GraphQL requests to the Django API without CSRF protection. The tutorial concludes with a summary of how to create a simple GraphQL API in Django using Graphene-Django.