The Twilio co-founders, Jeff, Evan, and John, discussed cloud telephony on the Web 2.0 Show, sharing insights into their service's origins, how to engage with the developer community, and various resources available for entrepreneurs, including startup events and industry reports. They also highlighted their use of lean startup principles in maintaining a agile business, as well as providing helpful resources such as API documentation, SDKs, and webinars on customer engagement. The conversation was recorded and made available on the Web 2.0 Show, offering valuable information for those interested in cloud communications and developer community engagement.