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Sending SMS without a phone number using alphanumeric sender IDs and Node.js allows for convenient notification of users about time-sensitive matters, while also providing benefits such as instantly identifiable business names and support across multiple countries. To achieve this, an upgraded Twilio account is required, along with a Messaging Service set up to handle alphanumeric sender ID messages. The process involves creating a new Messaging Service, adding an alphanumeric sender ID, setting up integration, and configuring compliance information. With the setup complete, Node.js code can be used to send SMS messages from the alphanumeric sender ID, making it possible for businesses to enhance their communication with users in various ways.