Securing Twilio webhooks in Python is crucial due to the risks associated with them. Webhooks can be vulnerable to phishing attempts and TwiML attacks, where an attacker can trick a webhook into performing actions on behalf of a user. Input data should never be trusted without validation, and webhooks should validate Twilio requests using cryptographic signatures. Verifying signatures eliminates replay attacks, but also requires the use of end-to-end encryption by hosting webhooks on HTTPS endpoints. With these measures in place, webhooks can be secured to prevent malicious activity.