Sam Agnew's guide provides a comprehensive walkthrough on scheduling tasks in Python using the Redis Queue (RQ) and RQ Scheduler, particularly focusing on setting up notifications for when the International Space Station (ISS) is overhead. The process begins with configuring the Python environment and installing necessary dependencies like the requests library, RQ Scheduler, and Twilio's REST API for sending text messages. Redis must be installed and running for these tools to function, and users are guided through writing functions to interact with the ISS Open Notify API to predict flyovers based on geographic coordinates. Agnew offers a detailed explanation of how to integrate Twilio for SMS alerts and utilizes RQ Scheduler to automate notifications. The guide includes instructions for testing the code and a creative "time traveling" method to verify functionality promptly. The tutorial concludes with ideas for further applications of RQ Scheduler, encouraging exploration of its potential in various Python scheduling tasks.