The Twilio Developer Contest is a weekly contest where developers are encouraged to try Twilio for different use cases, industries, and integrations. The contest aims to showcase the versatility of Twilio as a language-agnostic platform for cloud communications. Developers can submit their Python-powered Twilio apps by November 14th to be eligible to win a Graphite Amazon Kindle 3G, a $50 O'Reilly Gift Card, and $100 in Twilio credit. The contest is open to anyone who has submitted previously and did not win, making it an opportunity for developers to resubmit their apps for another chance at winning.