You can set up a conference call line using Twimlets with just a few steps. First, you need a Twilio account and 2 minutes of time. Then, head over to the Conference Twimlet page where you can configure settings such as moderators and hold music. Next, copy the URL and set it as the Voice URL for your Twilio Phone number. Finally, when you're ready to start the conference call, have people call a specific phone number, and everyone will be connected to the room. This setup requires no coding and is easily done using just Twimlets, making it a convenient solution for quick conference calls.