A Node.js-based Command-Line Interface (CLI) can be created using the ecosystem of packages available for the language, including npm and yarn. By leveraging these tools, developers can automate repetitive tasks while tapping into the vast array of CLI-focused packages, such as inquirer, email-prompt, chalk, ora, boxen, stmux, and listr. The CLI can also be distributed and consumed across multiple platforms, making it a versatile tool for various use cases. Additionally, npm init and yarn support bootstrapping projects using CLIs named create-*, allowing developers to easily set up new projects with specific configurations. By following this tutorial, developers can create their own CLIs using Node.js and explore the possibilities of automating tasks and customizing project setups.