Scaling outbound voice applications with Twilio requires careful consideration of several factors, including Calls Per Second (CPS), API concurrency, and queueing limitations. CPS is a per-account setting that determines the rate at which calls can be made, while API concurrency limits the number of simultaneous requests that can be made to Twilio's edge. Queueing limitations apply to voice workflows involving large numbers of callers in queues, where the maxSize parameter must be adjusted to accommodate the volume of traffic. Additionally, Twilio Studio and Functions have their own set of limitations, including concurrency limits for studio workflows and invocation limits for functions. To ensure a successful voice campaign, it is essential to follow industry best practices, adhere to legal compliance requirements, and maintain a positive caller reputation through strategies such as submitting numbers directly through the Free Caller Registry and registering for SHAKEN/STIR and CNAM. Furthermore, Twilio's Voice Integrity Trust Product aims to improve call answer rates and quality by registering phone numbers directly with analytic vendors and monitoring those numbers for mislabeling.