You can now chat with famous personalities through Twilio WhatsApp and Node.js using ChatGPT as the AI assistant, allowing users to interact with icons like Aristotle or Drake in a virtual conversation. To set up this service, you need a Twilio account, an OpenAI API key, Node.js v16+, and the ngrok CLI. You'll also need to sign up for a WhatsApp Business Profile and submit a request to enable your Twilio numbers for WhatsApp. The process involves setting up a Node.js application, installing dependencies, creating a folder called "famous-personalities" to store all project files, generating an AI personality response using the OpenAI Node.js Library and Twilio's Node Helper Library, and running the code with ngrok to create a publicly accessible URL that directs WhatsApp messages to your Node.js app.