Detecting sales leads using Twilio Conversations and Segment can help businesses respond to customer decisions more quickly. To set this up, users need to create a Twilio account and configure their Frontline interface, which uses the Conversations API to capture keywords related to readiness to buy. These keywords are then sent to Segment, where they are used to compute user traits such as buyer readiness stage. The resulting data can be used to trigger alerts in a CRM or send personalized messages to customers. By leveraging Twilio's Frontline and Segment's Personas feature, businesses can create a more agile sales process that responds quickly to changing customer needs.