To leverage native tools for handling formatting and time zone adjustments in Node.js, developers can utilize the Intl namespace's utilities, particularly Intl.DateTimeFormat. This tool provides fine-grained control over date and time formatting, including support for multiple time zones and localization. By using Intl.DateTimeFormat with specific settings, developers can convert and format dates to match different regions or locales without relying on external dependencies or modifying environment variables. This enables more reliable code across time zones, especially when deploying projects to remote servers or creating applications that require precise date formatting.