To configure a C# and .NET application for SendGrid, it's recommended to use environment variables and configuration APIs instead of hardcoding sensitive information. The `ConfigurationBuilder` class can be used to retrieve configuration from multiple sources, such as JSON files, user secrets, environment variables, and command-line arguments. The configuration can then be bound to strongly-typed objects using the `IOptions<T>` interface. The application can also use dependency injection to inject the SendGrid client into classes that need it. By using these techniques, developers can increase the flexibility and maintainability of their applications while ensuring secure configuration of sensitive information.