Connecting Twilio Studio with Salesforce CRM allows for real-time customer context access, enabling tailored interactions and intelligent routing. To achieve this, users need to set up a Salesforce API connection, create a certificate, and configure a connected app with OAuth settings. They then use Twilio Functions to host Node.js code that requests call routing data from Salesforce, using the Functions widget's ability to run JavaScript code directly on Twilio. The code retrieves customer information based on phone number and returns it as a JSON object, which is then parsed and used in a Studio flow to greet customers or play a message for new callers. Once set up, the flow can be integrated into a call center environment, enabling personalized interactions and improved customer experiences.