The guide provides step-by-step instructions on hosting a Python and Flask Facebook Messenger Bot on Heroku, covering the process of registering an account, setting up prerequisites such as requirements.txt, Procfile, and runtime.txt files, hooking up version control to Heroku, deploying the app, setting environment variables, and testing the bot. The guide assumes users have basic knowledge of Python, Flask, and Heroku, and provides examples and instructions for each step, including using config variables to securely store sensitive tokens such as access and verify tokens.