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The Twilio Video JavaScript SDK simplifies building multi-person video chat applications by minimizing complicated WebRTC boilerplate. To get started, create two web pages, local.html and remote.html, each with its own JavaScript code to accept conversation invitations and attach media to their respective divs. The client-side code uses the Twilio AccessManager to generate an access token, which is used to connect to a Twilio Video Conversation. Once connected, the code invites another participant to join the conversation using the `inviteToConversation` method. With these basic steps, you can create a bare-bones JavaScript application that runs with Twilio Video, serving as a foundation for more complex applications like Skype or integrating video chat into other projects.