Twilio and Go make it easy to integrate phone calls into your applications. To get started, create a basic web server using Go's net/http library, then use TwiML to provide instructions for the call. Ngrok can be used to expose the local port to Twilio. The example code demonstrates how to make a call using the Twilio REST API and play an mp3 file. With this knowledge, you can build applications that allow users to make and receive phone calls.