Keep doing biology with Prometheus

Researchers are encouraged to continue pursuing biology questions without allowing a single model provider’s refusal policies to dictate their workflow, using model routing as an engineering choice rather than a vendor-imposed limit. TrustedRouter’s Prometheus preset provides an OpenAI-compatible, attested gateway to a panel of open models, a judge, and a synthesizer for difficult or uncertain analyses, while cheaper models should be used for routine tasks they have already demonstrated they can handle. Initial BioMysteryBench-style tests found that Claude Opus 4.8 solved all three tasks, while lower-cost models such as Gemma-4-31b and GLM-5.2 completed two, with GLM uniquely solving a longer motif task, illustrating that performance varies by problem rather than following a simple ranking. The LLM-advisor skill and MCP server can help agents inspect available models, prices, privacy tiers, and task suitability before selecting a route. Prometheus is presented as useful when models offer complementary strengths, not as a solution to shared errors, which should instead be documented honestly; supporting benchmarks, routing tools, and setup materials are available openly.

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