To get the most out of Timescale Cloud, it's essential to tune key parameters such as background workers, memory allocation, and maintenance operations. Background workers perform critical processing for operations like live queries and background jobs, and their settings need to be carefully configured to avoid issues like User-Defined Actions not working properly or database size increasing rapidly. Memory allocation is crucial, with work_mem setting determining the amount of memory used by query operations, while maintenance_work_mem setting affects performance for VACUUM operations and database dump/restore. Shared_buffer settings can also impact performance, particularly for read-heavy workloads. By understanding these parameters and applying the recommended guidelines, users can diagnose and fix performance issues in their Timescale Cloud environment.