To create a simple hotel booking system using Strapi, first install Strapi by running `npx create-strapi-app my-project --quickstart` or `yarn create strapi-app my-project --quickstart`. Then, configure the backend API and database. Next, create a Nuxt.js project to build the frontend application. Install necessary packages such as `@nuxtjs/auth-next` for authentication and `@nuxtjs/strapi` for integrating Strapi with Nuxt.js. Build components such as the login, logout, and add guest pages. Integrate email functionality using Nodemailer to send emails to guests upon booking. The system allows users to add new guests, check them in and out, and receive notifications when a new booking is made.