Amazon S3 is an object storage service offered by AWS that requires proper configuration and security measures to prevent data breaches and compliance incidents. Misconfigured access policies, encryption settings, and lack of auditing can lead to sensitive data exposure. Compliance frameworks such as HIPAA, PCI, SOC 2, GDPR, and NIST 800-53 govern S3 usage and require regular audits to ensure configuration complies with policy. Conducting an audit of S3 resources, tracking changes using CloudTrail, and implementing encryption are essential measures to protect sensitive data. Regularly certifying that S3 configurations comply with policy, identifying and remediating misconfiguration events, and reporting on security incidents are also crucial tasks. Automating these processes can help prevent future breaches and ensure compliance. Tools like Fugue provide self-healing cloud infrastructure and automated remediation capabilities to support these efforts.