Provide granular permissions and groups for users in Azure Repos` highlights the importance of following the rule of least privilege by ensuring contributors exist in the correct groups and have necessary permissions to work, while restricting administrative actions whenever possible. The goal is to restrict access to sensitive areas of the repository. Monitoring changes in contributor requirements as they leave or step back from a project is also crucial. By implementing these best practices, users can ensure secure decisions are made for their Azure Repos projects.