Node.js applications are vulnerable to server-side request forgery (SSRF) attacks, which can expose sensitive data and cause significant damage. SSRF occurs when an attacker manipulates a server into making unintended requests to internal or external resources by input tampering or URL manipulation. To prevent SSRF vulnerabilities in Node.js applications, it is essential to sanitize user input, restrict access to trusted domains, use firewalls, enforce URL schemas, create allowlists of trusted domains, and utilize security tools like Snyk to detect vulnerabilities. By implementing these strategies and best practices, developers can significantly reduce the likelihood of SSRF vulnerabilities in their applications and protect their systems against potential attacks.