Node.js, Deno, and Bun are three JavaScript runtimes that cater to different needs and preferences. Node.js is the established leader with a vast ecosystem and a large community, but it can be slow in certain areas. Deno aims to improve security and offers modern features such as native TypeScript support and better web compatibility. Bun is the latest upstart, offering blistering speed and performance, but it's still in beta and has some gaps to fill out. When choosing a runtime, consider factors such as performance, stability, security, and additional features like TypeScript support and bundling capabilities. Each runtime has its strengths and weaknesses, and the right choice depends on individual needs and priorities.