Angular security best practices prioritize the use of interpolation ({{ }}) for safe encoding, avoiding concatenation of user input in templates, and using Angular's APIs to interact with HTML elements instead of native DOM APIs. The "Angular way" safeguards against Cross-site Scripting (XSS) vulnerabilities by default, while scanning open-source dependencies and components for security vulnerabilities is also crucial. Using tools like Snyk can help identify and fix potential issues in Angular projects, ensuring a secure web application.