Selenium is a widely used test automation framework that uses WebDriver to automate software tests within a web browser, supporting all major browsers and programming languages. However, it has some limitations, such as requiring separate configurations for each browser and being less suitable for mobile app testing. On the other hand, Cypress is a newer testing framework that relies on native Web and browser APIs to interact with web apps, making it easier to set up but only supporting JavaScript applications and certain browsers. Cypress also provides limited support for mobile app testing. When choosing between Selenium and Cypress, developers should consider their priorities, such as writing tests quickly or taking screenshots during testing, and whether they want to involve front-end developers in software testing or cater to QA professionals who are willing to invest time in learning the Selenium platform. Ultimately, both frameworks can be used together to achieve a balance of needs.