Developing with React can introduce complexity in debugging, especially when using hooks like useEffect, which can be configured to run conditionally, potentially leading to issues when expectations aren't met. A real-world example is detailed involving a bug in Replay DevTools where a tooltip displaying line hit counts got stuck in a loading state intermittently. The debugging process involved creating a reproducible example, understanding expected behaviors, isolating the issue to a stale sourceId not updating due to a closure in JavaScript, and tracing the problem to the closure effect within a useEffect hook. The fix was implemented by updating the useEffect hook to run whenever the source value changes, ensuring the correct sourceId is used. This example illustrates the importance of understanding closures in JavaScript and the behavior of useEffect to effectively debug and resolve issues in React applications.