ReadMe facilitates collaborative documentation efforts by allowing team members from different departments, such as technical writers and API engineers, to edit documents seamlessly from either ReadMe's user interface or a connected GitHub repository. The integration with GitHub enables bi-directional synchronization, ensuring that changes made on either platform are reflected in real-time across the other. Setting up this synchronization involves connecting a ReadMe project to an empty GitHub repository and installing the ReadMe Sync GitHub App to manage permissions. Once connected, the structure of ReadMe's content in GitHub mirrors that of the ReadMe project, with folders corresponding to categories and an order.yaml file dictating page order. Changes can be made in either ReadMe or GitHub, with full edit histories and versioning supported through Git branches, allowing for efficient and organized documentation management.