The principles of the Zen of Python, a set of axioms introduced by typing "import this" in the Python REPL, are highlighted as vital guidelines for writing high-quality, maintainable code. Emphasizing explicitness over implicitness helps prevent misunderstandings, while readability is enhanced through meaningful naming and proper structuring, supported by Python's indentation rules. The Zen advises simplicity over complexity to maintain software, with abstractions in libraries like Typer and FastAPI showcasing this principle. The importance of flat structures over nested ones is underscored, as deeply nested code indicates complexity, which can be measured using tools like Flake8's complexity checker. Practicality is also emphasized, acknowledging the need to balance idealism with real-world demands, such as shipping code quickly while maintaining quality. The Zen's guidance on explaining implementations underscores the value of clarity and understanding before coding. Overall, these principles aim to make Python code more maintainable and enjoyable to work with, while reducing errors, and developers are encouraged to reflect on these axioms to improve their coding practices.