This comprehensive guide details how to create and monetize HTML5 multiplayer games using PubNub, a cloud-hosted service for real-time data streaming. It emphasizes the use of PubNub's capabilities to engage players through real-time interaction and analytics, and explains how players can earn message credits during gameplay, which can be used for continued access to PubNub services. The guide highlights the importance of integrating CSS3 animations for enhanced user experience and suggests using JSONP for data transport due to its compatibility advantages. Additionally, it discusses security measures such as client and server logic, SSL encryption, and message signing to protect data integrity, as well as the importance of setting up payment gateways for monetization. The tutorial also covers the use of PubNub's APIs for easy data streaming across multiple platforms, ensuring game compatibility with various web browsers and mobile devices, and provides resources for developers to build robust multiplayer gaming experiences.