Organizations handling electronic protected health information (ePHI) must ensure compliance with the Health Insurance Portability and Accountability Act (HIPAA), which has seen significant updates aimed at strengthening cybersecurity and privacy, especially concerning real-time technologies. Recent amendments proposed by the U.S. Department of Health and Human Services (HHS) to the HIPAA Security Rule include mandatory multifactor authentication, enhanced encryption standards, and regular risk assessments to combat increasing cyber threats. Additional revisions to the HIPAA Privacy Rule enhance protections for reproductive health information, while the Health Information Technology for Economic and Clinical Health (HITECH) Act amendment emphasizes adopting recognized security practices, such as the NIST Cybersecurity Framework, to mitigate penalties for violations. Compliance requires organizations to update administrative, technical, and physical safeguards, including risk management, business associate agreements, employee training, access controls, encryption, and audit controls. Real-time technology considerations, such as vendor compliance, data integrity, and patient consent, are crucial for telehealth and instant messaging applications. PubNub offers a secure real-time platform that ensures HIPAA compliance through end-to-end encryption, secure chat and telehealth capabilities, real-time monitoring, and scalable infrastructure to support healthcare operations.