The article explains how to integrate PlanetScale with Node applications built using the Serverless Framework on AWS, providing a serverless stack with extreme scalability and simplicity. To start, users need an AWS account and install the serverlessCLI, then create a new serverless application using the Serverless Framework's configuration file (serverless.yml). The application is then connected to PlanetScale as its database, using environment variables to store credentials securely. Stage parameters allow for different credentials to be used depending on the deployment stage, making it easy to test and deploy changes between development and production environments.