Migrating from Postgres to MySQL requires an understanding of the differences between the two relational databases, including data types, spatial data handling, UUIDs, and JSON support. MySQL lacks support for certain Postgres data types, such as jsonb, but can be used with alternatives like varchar or text. Spatial data handling differs between the two databases, requiring additional processing in MySQL to access coordinates. The UUID data type can be migrated using a 36-character string, while the Postgres-specific JSONB data type can be handled by using the JSON data type and leveraging its features, such as indexing and updating. Other differences include the use of triggers, temporary tables, and stored procedures, which may require adjustments during migration. Understanding these differences is crucial for a successful migration to MySQL.