Laravel's safety features can help prevent painful mistakes, including N+1 prevention, partially hydrated model protection, attribute typos and renamed columns, mass assignment protection, model strictness, polymorphic mapping enforcement, preventing stray HTTP requests, and long-running event monitoring. These features are designed to ensure application correctness and performance, and can be enabled in various environments to prevent issues such as data loss, overwriting data, and silent failures. By enabling these protections, developers can focus on writing correct code rather than worrying about potential pitfalls.