New Relic Synthetics offers powerful application monitoring and troubleshooting capabilities that enable teams to simulate real user flows and behavior at any frequency from locations around the world. The guide provides insider tips and best practices for organizations just starting their journey with Synthetics, including setting up a naming convention for synthetic monitors, setting appropriate permissions, and using the REST API to manage monitors programmatically. Secure credentials are also essential for storing sensitive data within Scripted Browsers and other scripted monitoring tools deployed across the Synthetics environment. Understanding New Relic Synthetics data is crucial, including interpreting failures, scripts, and logs to diagnose and respond to monitor failures. Insights queries can be used to make data actionable, while custom alerts using NRQL can set up alternate alert configurations. The guide also provides resources for learning more about Synthetics best practices and tips.