Smoke testing in production is a crucial aspect of ensuring seamless deployments and reducing risks for end-users. By leveraging synthetic monitors for automation, teams can ensure that critical functionalities are working as expected, catch major issues before they affect users, and improve overall software quality. Automated smoke tests can be integrated into continuous integration pipelines for even quicker results, while hybrid smoke testing combines manual and automated approaches to cover all the basics. To set up effective smoke testing in production, developers should define the scope, prepare the test environment, execute smoke tests, document results, investigate failures, take corrective actions, and continuously improve their process. Additionally, synthetic monitors like New Relic Synthetics can be used to automate smoke testing, providing performance, functionality, and availability testing for reliable continuous delivery. By incorporating smoke testing into their deployment processes, organizations can deliver reliable and high-performing software to their customers while reducing risks and downtime.