AWS GuardDuty is a threat detection service that protects AWS accounts, workloads, and data. It can be combined with AWS CloudTrail and New Relic One to monitor cloud services for threats. The integration allows users to correlate security events with other telemetry data, visualize them in dashboards, alert teams for faster resolution, retain data beyond AWS quotas, and receive alerts via EventBridge and a Kinesis Firehose delivery stream. It also provides use cases such as mitigating SSH brute force attacks and detecting publicly accessible S3 buckets, enabling users to speed up remediation and gain visibility into security issues in their AWS environment.